The objective of this study was to investigate the pH-dependent solubility and dissolution of weakly basic Biopharmaceutical Classification Systems (BCS) class II drugs, characterized by low ...

High-concentration injectable formulations present unique challenges. Poor solubility issues are often associated with small-molecule APIs formulated for oral administration. Solubility is also ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Improving the aqueous solubility of poorly soluble hydrophobic compounds is a topic of ...

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Modern methods and modeling offer a better way to understand solubility issues and solve today’s complex formulation challenges. Poor solubility is an ongoing challenge in pharmaceutical development.