The San Francisco 49ers, entering a Week 18 matchup at home against the Seattle Seahawks, will be fighting for a chance to clinch the NFC West, the NFC's top seed, and a first-round bye. There's no bigger matchup than this one,

The San Francisco 49ers will face the Seattle Seahawks in Week 18, and cornerback Deommodore Lenoir already knows what he wants his assignment to be.

NFL.com's Eric Edholm breaks down two must-know storylines for when the Seattle Seahawks play the San Francisco 49ers on Saturday evening.

Sam Darnold and the Seahawks have won six in a row to take a one game lead into the final game of the regular season. Seattle is outscoring its opponents 29-18. Their stifling defense has allowed just 31 touchdowns through 16 games including just one last weekend in Charlotte to the Carolina Panthers in a 27-10 win.

It feels like an eternity ago that Sam Darnold and Jaxon Smith-Njigba were lighting opposing defenses on fire with long touchdowns and big gains weekly. That's because it's been nearly two months since we've seen what was once the most dangerous passing offense in the league.

Here's everything you need to know when the Seattle Seahawks play the San Francisco 49ers Week 18 of the 2025 NFL season.

Mike Florio and Chris Simms dive into the Seattle Seahawks vs. San Francisco 49ers matchup that will decide the winner of the NFC West as well as the conference's No. 1 seed.

The 49ers took Round 1 in Seattle on opening day. Last year the Seahawks memorably beat the 49ers on the road to end a three-year losing streak against them. Can they make it two years in a row of winning at Levi’s Stadium, and can Mike Macdonald make it three years between his time in Seattle and as defensive coordinator of the Baltimore Ravens?