実はPDE阻害薬は、慢性閉塞性肺疾患（COPD）に対しても有効です。気管支拡張作用、抗炎症効果、線毛運動機能の改善といった複数の機序によって、COPDの病態を改善するとされています。海外ではロフルミラスト（roflumilast）というPDE4阻害薬が用いられてい ...

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The 11 known phosphodiesterase (PDE) families comprise at least 60 distinct PDE species. They differ in their substrate specificity, their kinetic properties, and in their tissue distribution (Table 1 ...

Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, China Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive ...

When you or your child has atopic dermatitis, your doctor might prescribe a topical medication (the kind you apply to your skin). Topical steroids are widely used. But sometimes these don’t work well ...

Abstract: The use of evolutionary algorithms (EAs) to solve problems with multiple objectives (known as multi-objective optimization problems (MOPs)) has attracted much attention. Being population ...

The authors offer recommendations for permissible daily exposures and concentration limits of elemental impurities for dermal drug products. The International Council for Harmonization Guideline for ...

Abstract: We present designs for exponential stabilization of an ordinary differential equation (ODE)-heat partial differential equation (PDE)-ODE coupled system where the control actuation only acts ...

Our method, termed Latent Evolution of PDEs with Uncertainty Quantification (LE-PDE-UQ), endows deep learning-based surrogate models with robust and efficient uncertainty quantification capabilities ...