Homologous recombination involves the precise exchange of similar or identical nucleic acid sequences between two DNA molecules. This process directs the repair of many DNA lesions in somatic cells ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

The efficient repair of double-stranded DNA breaks (DSBs) is essential for genome integrity and cell survival. Homologous recombination is one pathway that is used to repair DSBs, particularly in ...

The DNA mismatch repair (MMR) system is a highly conserved post replicative editing process that prevents mutations (for a review see Kolodner, 1996; Modrich and Lahue, 1996). Germline mutations in ...

Repair of broken chromosomes and triggering of the DNA damage response Broken chromosomes must be repaired if a cell is to survive; consequently cells have evolved a variety of mechanisms to repair ...

Maintenance of genomic integrity and stable transmission of genetic information depend on a number of DNA repair processes. Failure to faithfully perform these processes can result in genetic ...