A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease ...

Huntington's disease is a neurodegenerative disorder that is usually fatal about 15 to 20 years after a patient is diagnosed. It is known to be caused by an aberrant repetitive sequence (CAG) in the ...

DNA repair mechanisms are crucial for the survival and growth of cells. Through a comprehensive analysis, a research team at ETH Zurich has identified numerous redundancies between the genes involved ...

Researchers from the Hubrecht Institute and their collaborators at other institutions have used a protein from zebrafish dubbed Hmga1 which plays a key role in heart regeneration, to reactivate heart ...

Circulating Tumor DNA as a Prognostic Biomarker for Recurrence in Patients With Locoregional Esophagogastric Cancers With a Pathologic Complete Response PD-1 inhibition is effective in patients with ...

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in ...

Investigation of cancer predisposition in Fanconi anemia heterozygotes: A DiscovEHR cohort population study. Pts with PARPi-eligible PGVs by region and cancer type. Region Median # of genes testedBC ...

Artistic representation of heart regeneration: Hmga1 in green symbolically flows from the border zone of a zebrafish heart (top right) to the injured border zone of a mouse heart (left). Red ...

The DNA of human cells consists of a sequence of about 3.1 billion building blocks. Cells go to great lengths to maintain the integrity of this vast store of information. They constantly untangle ...