For large-scale industrial production of high-value therapeutic proteins, mammalian cell lines form a vital platform. Unfortunately, this production is often hampered by low predictability and ...

Low levels of λ repressor (CI) can autoenhance expression and lysogeny (quiescence) of bacteriophage λ infection. However, additional CI mediates an autorepressive DNA loop. Supercoiling catalyzes ...

The basic underlying problem in reverse engineering of gene regulatory networks from gene expression data is that the expression of a gene encoding the regulator provides only limited information ...

Hepatocytes are the major cell-type in the liver responsible for the coordination of metabolism in response to multiple signaling inputs. Coordination occurs primarily at the level of gene expression ...

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A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...