The SportsLine Projection Model is high on the road team. It has the Colts covering the spread in 57% of simulations and ...

After an 0-3 start, the Houston Texans are playoff bound. And depending on what happens in Week 18, still have a chance at ...

A teen accused of carrying out a deadly shooting at a Georgia high school debuted a drastically different appearance during his court hearing on Tuesday, according to photos. A handcuffed Colt Gray, ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

Should DFS managers target Brock Purdy or Philip Rivers on tonight's Monday Night Football DraftKings Showdown slate?

49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...

A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.

Purdy's career night kept the 49ers in the hunt for the NFC's top seed and dampened the Colts' already faint playoff hopes.

Preview the Week 16 matchup between the San Francisco 49ers and Indianapolis Colts with predictions, odds, over/under, spread, betting lines and more.

The Indianapolis Colts host the San Francisco 49ers on "Monday Night Football" in NFL Week 16 action. Both teams are watching injuries in the wake of Week 15 games. The Colts, who are without right ...

Break down the 49ers' Week 16 win with PFF grades, snap counts, and top performers—who stood out and who struggled vs. the Colts.